Biologics are the newer generation of DMARDs. Biologics are genetically engineered protein to act like natural proteins and attach to the antibodies attacking joint tissues leading to reducing inflammation. Biologics as well as DMARDs are considered immunosuppressive drugs which make RA patient more susceptible to infections. Unlike DMARDs, biologics are more specific and block certain inflammatory responses. Most rheumatologists do not give biologics unless DMARDs pharmacologically fails and can not cause any progress. RA patients who take biologics should consider that their risks of getting infected by opportunistic bacteria such as TB are higher than normal people. The most commonly used biologics are Humira (adalimumab), Enbrel (etanercept), Remicade (infliximab), and Rituxan (rituximab).