Who is Affected?
Hemophilia A is about four times as frequent as hemophilia B.
As hemophilia A and B are both X-linked recessive disorders, it is popular in males, and females are unusually affected.
Some women with an abnormal gene on one of the X chromosomes may be kindly symptomatic.
Hemophilia C occurs equally in both sexes and mostly in Ashkenazi Jews.
In the 1800s, hemophilia B was well-known within the royal families of Europe.
› Diagnosis depends on the analysis of the blood capability to clot and the levels of clotting factors.
› Prevention may occur by separating an egg, fertilizing it, and examining the embryo before transferring it to the uterus.
› Treatment is by substituting the absent blood clotting factors. We do that regularly or during bleeding episodes. We can do this replacement at home or in the hospital.
Hemophilia A
Hemophilia A is a hereditary disorder caused by defective clotting factor VIII. Other names are factor VIII (FVIII) deficiency or classic hemophilia
Although hemophilia is a genetic disorder passed down from parents to children, about 1/3 of cases appear due to a spontaneous mutation.
