4) Severe pruritus
Severe pruritus (itchiness) is a common symptom of jaundice, which occurs when bile acids accumulate in the body.
The mechanism of how bile acids cause pruritus is not entirely understood. However, it is believed to be related to the stimulation of nerve terminals. Bile acids are considered to activate nerve endings in the skin, leading to intense itching. Furthermore, bile acids can also reduce the skin’s ability to retain moisture, leading to further itching.
It is important to seek medical attention if you suffer from severe itching or jaundice, as it may be a sign of cholestasis or another underlying medical condition. It is also important to note that cholestasis can lead to other serious complications, such as liver damage, so early detection, and treatment are essential.