Causes and risk factors of Peyronie’s disease
The exact cause of Peyronie’s disease is unknown, but the most common cause is penis injuries. Penis injuries may occur during sex -especially violent sex-, sports, or accidents. Scarring of the tunica albuginea occurs during the healing process because the body can’t control how much fibrous tissue needs to heal the injury. Peyronie’s disease doesn’t affect all people who exposed to penile trauma; there are some risk factors predispose to the condition, such as:
- Positive family history of Peyronie’s disease: People with a family history of Peyronie’s disease may have previous problems in wound healing in other parts of the body rather than the penis.
- Age raises the risk of Peyronie’s disease; it is more common among those over 50 years old.
- Connective tissue diseases: The risk of Peyronie’s disease is higher in those with connective tissue diseases, such as Dupuytren’s contracture (scarring of the subcutaneous tissue of the palms, which restricts the movement of the palm, and extends to some fingers causing their flexion).
- Other factors, such as Diabetes Mellitus, smoking, alcohol abuse, pelvic trauma, and some prostatic surgeries, may cause abnormalities in wound healing.
» The clinical picture of Peyronie’s disease starts from the scar of the tunica albuginea and the loss of elasticity of this scarred part.