6. Adjuvant chemotherapy:
In cases where there is extensive affection of the liver by the lesions or if there is vascular invasion or extra hepatic metastasis, systemic chemotherapy is used as the main line of treatment with sorafenib, an oral multikinase inhibitor being the first line of treatment of advanced HCC. It acts mainly by blocking the tumors ability to make new blood vessels leading to its shrinkage to smaller sizes.
